Evolution of modern humans is a story of humans taking lead position in the proceedings of Earth. Development of Science unmasked Universal truths to humans and helped them to devise systems and means to ensure a higher quality of life. Journey of development of Science is finding answers to what is happening, why is it happening and when would it happen. In addition to explanation of past and current events, Science need to explain what would happen in future and what would have happened in unknown past. This course is a journey through Scientific progress in early human civilisations, medieval progress in Scientific thoughts, Temporary ups and down in Scientific progress in select regions, Lives of famous Scientists, Importance of specific discoveries, Factors that kept Scientific progress in abeyance, Renaissance and evolution of modern Science, Unsolved puzzles, Current areas of research and some future thoughts. The course navigates through planetary motion, Geo/Helio centric models of Universe, Newtonian physics, Quantum Mechanics, Light, Big Bang, Particle physics etc.